Emmanuel Mignot

Emmanuel Mignot appears in Wake-up haul: an Ozempic moment for the brain as the Stanford researcher whose late-1990s dog work helped connect narcolepsy to orexin biology. The episode says he studied narcolepsy in breeds such as Dobermans and Labradors and linked the condition to a mutation that made the dogs fail to respond to orexin.

The source uses Mignot as the discovery bridge between observable sleep-wake disruption and the later drug-development story around Orexin Agonists. Human trials are described as supporting the idea that narcolepsy patients lack enough orexin molecules in the brain.

Connections

• Stanford University - institutional context named in the source.
• Narcolepsy Wake-Sleep Boundary and Orexin Agonists - scientific and drug-development context.
• Shailesh Chitnis - segment explainer.